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Description

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Regulatory requirements for Phase III trials in China and Turkey, evaluating a complex molecule as a generic in Canada, or manufacturing issues, such as water quality consistency in Saudi Arabia, has already contributed to these delays

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A Bayesian hierarchical model was fitted using the brms framework, specifying percent weight change as a Gaussian outcome with (i) drug-specific smooth dose effects (splines by drug), (ii) treatment duration included as a covariate to account for variability in follow-up time across trials, and (iii) a study-level random intercept to account for between-trial heterogeneity

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Single-step isolation of extracellular vesicles by size-exclusion chromatography

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