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These patients also exhibit deficits in auditory sensory processing that manifests as impaired mismatch negativity (MMN), which is an auditory evoked potential (AEP) component related to NMDA receptor function
This pattern suggests GHK-Cu provided temporary stimulation rather than inducing self-sustaining structural changes, requiring continuous or cyclical application for maintaining optimal results
Full Staggered Titration Schedule Recommended staggered co-titration across 24 weeks Phase Tirz initiation Weeks 1-4 Tirzepatide 2.5 mg/week Cagrilintide Not started Notes Confirm tirzepatide GI tolerance first
2018, Roomi et al
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